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Mouse anti-Human CD41, FITC Conjugated mAb.
[GMH0411F]
Product Details

Catalog No./Size: GMH0411F-025/25 Tests
GMH0411F-100/100 Tests
Vol.per.Test: 10 μl/Test
Clone: GM1CD41
Isotype: Mouse IgG1
Reactivity: Human,Not yet tested in other species.
Workshop: N/A
Storage Buffer: Phosphate-buffered solution, pH 7.4, containing 0.09% sodium azide and 0.2% (w/v) BSA
Storage Condition: Store at 4°C.DO NOT FREEZE. LIGHT SENSITIVE MATERIAL.
Applications: Flow Cytometry
Applications Notes:

FACS: Use 10µl for 106 cells

Description:

GM1CD41 reacts with a calcium-dependent complex of CD41/CD61 ( GPIIb/IIIa), 135/120 kDa, expressed on normal platelets and megakaryocytes. CD41 antigen acts as a receptor for fibrinogen, von Willebrand factor (vWf), fibrinectin and vitronectin and mediates platelet adhesion and aggregation. GM1CD41 antibody completely inhibits ADP, epinephrine and collagen-induced platelet activation and partially inhibits restocetin and thrombin-induced platelet activation.  It is useful in the morphological and physiological studies of platelets and megakaryocytes.
* Application: Diagnosis of Glanzmann's Thrombasthenia and megakaryoblastic leukemias, deletion of alloantibodies, and anti-thrombotic therapy.

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