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Mouse anti-Human CD40, Purified mAb.
[GMH040Z]
Product Details

Catalog No./Size: GMH040Z-025/25 Tests
GMH040Z-100/100 Tests
Vol.per.Test: 10 μl/Test
Clone: GM1CD40
Isotype: Mouse IgG2a
Reactivity: Human,Not yet tested in other species.
Workshop: N/A
Storage Buffer: Phosphate-buffered solution, pH 7.4, containing 0.09% sodium azide and 0.2% (w/v) BSA
Storage Condition: Store at 4°C.DO NOT FREEZE. LIGHT SENSITIVE MATERIAL.
Applications: Flow Cytometry
Applications Notes:

FACS: Use 10µl for 106 cells

Description:

GM1CD40 reacts with CD40 ( Bp50 ),  a  member of the TNF receptor family  with 48 kDa MW.  which  is expressed  on B lymphocytes including pro-B through to plasma cells but not on monocytes nor granulocytes. CD40 also expressed on dendritic cells and CD34+ hemopoietic cell progenitor. CD40 molecule involved in regulation of B-cell growth, differentiation and Isotype-switching of Ig and up-regulates adhesion molecules on dendritic cells as well as promotes cytokine production in macrophages and dendritic cells. CD40 antibodies has been reported to co-stimulate B-cell proleferation with anti-m or phorbol esters. It may be an important target for control of graft rejection, T cells and antibody-mediated  autoimmune diseases.
This clone is cross reactive with non-human primate .

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