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Mouse anti-Human CD25,Purified mAb.
[GMH0251Z]
Product Details

Catalog No./Size: GMH0251Z-025/25 ug
GMH0251Z-100/100 ug
Clone: GM1CD25
Isotype: Mouse IgG2a
Reactivity: Human,Not yet tested in other species.
Workshop: N/A
Storage Buffer: Phosphate-buffered solution, pH 7.4, containing 0.09% sodium azide
Storage Condition: Store at 4C.
Applications: Flow Cytometry
Applications Notes:

FACS: The suggested use of this reagent is 0.25 µg per 106 cells in 100 µl volume.
It is recommended that the reagent be titrated for optimal performance for each application.

Description:

GM1CD25 reacts with CD25 antigen, a chain of low-affinity interleukin-2 receptor ( IL-2Ra ), which is expressed on activated cells including T, B, NK cells and monocytes. The antigen also prsent on subset of thymocytes, HTLV-1 transformed T cell lines, EBV transformed B cells, myeloid precursors and oligodendrocytes. The high affinity IL-2 receptor is formed by the noncovalent association of of a ( 55 kDa, CD25 ), b ( 75 kDa , CD122 ), and g subunit ( 70 kDa, CD132 ). The interaction of IL-2 with IL-2R induces the activation and proliferation of T, B , NK cells and macrophages. CD4+/CD25+ cells might directly regulate the function of responsive T cells.

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