suggested use of this reagent is 0.5 µg per 106 cells in 100 µl
It is recommended that the reagent be titrated for optimal performance for
GM1CD22 reacts with CD22, a 140 kDa
B-cell specific molecule, expressed in the cytoplasm of all B
lymphocytes and on the cell surface of only mature B cells. CD22 antigen
is present in the most B-cell leukemias and lymphomas but not T-cell
leukemias. In contrast with CD10, CD19 and CD20 antigen, CD22 antigen is
still present on lymphoplasmacytoid cells but is dininished on the fully
mature plasma cells. CD22 is an adhesion molecule and plays a role in B
cell activation as a signaling molecule.
*CD22 antibody has been used to treat leukemia and lymphoma.