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Mouse anti-Human CD152, PE-Cy5 Conjugated mAb.
[GMH152C]
Product Details

Catalog No./Size: GMH152C-025/25 Tests
GMH152C-100/100 Tests
Vol.per.Test: 10 μl/Test
Clone: A3.6B10
Isotype: Mouse IgG2a
Reactivity: Human,Not yet tested in other species.
Workshop: N/A
Storage Buffer: Phosphate-buffered solution, pH 7.4, containing 0.09% sodium azide and 0.2% (w/v) BSA
Storage Condition: Store at 4C.DO NOT FREEZE. LIGHT SENSITIVE MATERIAL.
Applications: Flow Cytometry
Applications Notes:

FACS: Use 10l for 106 cells

     
  CD152 PE-Cy5  
     
     
Description:

CD152(CTLA-4).which is expressed on activated T lymphocytes 2-3 days after stimulation through T cell receptor.CTLA-4 has significant similarity to CD28 in amino acid sequence,structure and genomic organization.Furthermore CD152 and CD28 share common B7 family counter-receptors.Unlike CD28,CD152 expression appears to be restricted to activated T cells and CD25+CD4+ regulatory T(Treg) cells. The regulation of CTLA-4 protein expression is complex and can involve changes in the rate of transit between intracellular stores and the cell surface. Where as CD28 delivers a costimulatory signal required for T-cell activation, CTLA-4 is a negative regulator of cell-mediated immune responses.CD152 may play roles in induction and/or maintenance of immunological tolerance regulation of protective immunity and autoimmune responses and regulation of some aspects of thymocyte maturation.



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