TS1/188.8.131.52 reacts with CD11a, a
180 kDa molecule. CD11a is the a chain of the leukocyte function
associated antigen-1 (LFA-1a), and is expressed on all leukocytes
including T and B cells, monocytes, and granulocytes, but is absent on
non-hematopoietic tissue and human platelets. CD11/CD18 (LFA-1), a
member of the integrin subfamily, is a leukocyte adhesion receptor that
is essential for cell-to-cell contact, such as lymphocyte adhesion, NK
and T-cell cytolysis, and T-cell proliferation. CD11/CD18 is also
involved in the interaction of leucocytes with endothelium.
*CD11a antibody has been used to reduces graft failure for bone marrow
grafts in immunodeficient children.
This clone is cross reactive with non-human primate.