suggested use of this reagent is 0.25 µg per 106 cells in 100 µl
It is recommended that the reagent be titrated for optimal performance for
GM2CD11 reacts with CD11b, a member
of the integrin a chain family with 165 kDa MW. which is expressed on NK
cells, monocytes, granulocytes and subsets of T and B cells. It
associates with CD18 to form CD11b/CD18 complex .The cellular function
of CD11b is on neutrophil and monocyte interactions with stimulated
endothelium; Phagocytosis of iC3b or IgG coated particles as a receptor;
Chemotaxis and apoptosis.
* CD11b is absent in Leukocyte Adhesion Deficiency (LAD-1) patients who
have major problems with bacterial infections.
This clone is cross reactive with non-human primate.